The Structural Biology group operates a world leading suite of synchrotron radiation beamlines dedicated to the study of biological macromolecules:
Structural biology research
Research performed at the ESRF produces over 20% of the protein structures submitted in the world and accounts for over 50% of those that come from Europe. To see a list of structures solved at the ESRF, see the BIOSYNC website. Please also consult our recent highlights.
The evolution of the facility, in the context of the ESRF upgrade, is encompassed within UPBL10/MASSIF. This facility, to be located at beamlines ID30 and BM29, will have at its core three beamlines optimised for highly automated, high-throughput sample evaluation.
Many of the world's leading pharmaceutical companies carry out proprietary research on our beamlines developing future drug candidates. Industrial clients can access our facilities through our mail-in crystallography service MXpress or by applying directly for beamtime. See the Industry website for details.
In-house research runs in parallel to beamline operation, helping us to perfect techniques while investigating key scientific areas. Current projects include:
- Beamline instrumentation (Kappa gonimeters, dehydration devices, sample characterisation)
- The molecular basis of the extreme radiation resistance of Deinococcus radiodurans
- Structural studies of enzymatic transition states
- Activation mechanisms of LysR transcription regulators.
A number of laboratories and facilities are available to the community. Of particular interest is The Partnership for Structural Biology (PSB) which is a collaboration between ESRF, EMBL, ILL and IBS to bring together a set of complementary technologies for structural biology.
- The Partnership for Structural Biology
- Cryo-Bench Laboratory
BM14 - ESRF beamline managed and operated by a consortium between EMBL and NII, India, permitting European and Indian access. Both public (ESRF) and consortium beamtime (40 and 60%, respectively) are offered.
Collaborating Research Group beamlines