Structure dynamics of microtubules revealed by small- and wide-angle X-ray fiber diffraction
Extraordinary Biomed Seminar
by Shinji Kamimura
Prof. Kamimura is interested in the molecular mechanisms of cell motility, in particular the structural background of motor proteins and cytoskeletons, and their evolutionary meaning. i.e., how the polypeptide components and their molecular configurations are optimized for their specific functions. Biological filaments such as microtubules can be readily aligned by shearing flows under various physiological buffer conditions in order to acquire structural periodicity data. In his talk, Prof. Kamimura will provide an introduction of the aligning technique and application to 2D-SAXS/WAXS analysis of microtubules.He will also present recent evidence on how the structures of microtubules as well as their unit molecules, tubulin, are modified depending on various chemical and physical conditions.
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