ID29 MX tunable microbeam

Techniques

MX - macromolecular crystallography

MAD - multi-wavelength anomalous dispersion

Energy range

6.0 - 20.0 keV

Beam size

Minimum (H x V) : 10.0 x 10.0 µm²
Maximum (H x V) : 40.0 x 30.0 µm²

Technical details

ID29 is intended for high intensity, high energy resolution MAD and SAD measurements over a wide range of X-ray wavelengths (0.7 - 2.1 Å). ID29 is equipped with a MicroDiffractometer (MD2) - which allows to tailor the beam sizes down to 75 (full beam), 50, 30, 20 and 10 microns in diameter - and with a FlexHCD Sample Changer. Diffraction data are recorded with a fast readout Pilatus 6M-F pixel detector detector (Dectris LTD) that allows data collection with a maximum frame rate of 25 images/s.

Human antibodies that slow erythrocyte invasion potentiate malaria-neutralizing antibodies

Alanine D.G.W., Quinkert D., Kumarasingha R., Mehmood S., Donnellan F.R., Minkah N.K., Dadonaite B., Diouf A., Galaway F., Silk S.E., Jamwal A., Marshall J.M., Miura K., Foquet L., Elias S.C., Labbe G.M., Douglas A.D., Jin J., Payne R.O.., Illingworth J.J., Pattinson D.J., Pulido D., Williams Barnabas G., de Jongh W.A., Wright G.J., Kappe S.H.I., Robinson C.V., Long C.A., Crabb B.S., Gilson P.R., Higgins M.K., Draper S.J.,
Cell 178, 216-228 (2019)

HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs

Pabis M., Popowicz G.M., Stehle R., Fernández-Ramos D., Asami S., Warner L., García-Mauriño S.M., Schlundt A., Martínez-Chantar M., Díaz-Moreno I., Sattler M.,
Nucleic Acids Research 47, 1011-1029 (2019)

Structural evidence for an essential Fe-S cluster in the catalytic core domain of DNA polymerase epsilon

ter Beek J., Parkash V., Bylund G.O., Osterman P., Sauer-Eriksson A.E., Johansson E.,
Nucleic Acids Research 47, 5712-5722 (2019)

Caractérisation biochimique et structurale de bactériocines ciblant le métabolisme du peptidoglycane bactérien, alternative potentielle aux antibiotiques

Chérier D.
From: Université Paris-Saclay, France (PhD Thesis), 2017

Ingénierie de l’architecture protéique artificielle αRep : élaboration de catalyseurs biohybrides par couplage covalent de complexes métalliques

Di Méo T.
From: Université Paris-Saclay, France (PhD Thesis), 2017

Inhibition of the bacterial ribosome by nascent and antimicrobial peptides

Seefeldt A.C.
From: Université de Bordeaux, France (PhD Thesis), 2017