Publications RSS feed from the library

Discovery of a chemical probe bisamide (CCT251236): An orally bioavailable efficacious pirin ligand from a heat shock transcription factor 1 (HSF1) phenotypic screen

Cheeseman M.D., Chessum N.E.A., Rye C.S., Pasqua A.E., Tucker M.J., Wilding B., Evans L.E., Lepri S., Richards M., Sharp S.Y., Ali S., Rowlands M., O'Fee L., Miah A., Hayes A., Henley A.T., Powers M., te Poele R., De Billy E., Pellegrino L., Raynaud F., Burke R., van Montfort R.L.M., Eccles S.A., Workman P., Jones K.,
Journal of Medicinal Chemistry 60, 180-201 (2017)

De novo active sites for resurrected Precambrian enzymes

Risso V.A., Martínez-Rodríguez S., Candel A.M., Krüger D.M., Pantoja-Uceda D., Ortega-Muñoz M., Santoyo-González F., Gaucher E.A., Kamerlin S.C.L., Bruix M., Gavira J.A., Sánchez-Ruiz J.M.,
Nature Communications 8, 16113-1-16113-13 (2017)

Thieno[3,2-b]pyrrole-5-carboxamides as new reversible inhibitors of histone lysine demethylase KDM1A/LSD1. Part 1: High-throughput screening and preliminary exploration

Sartori L., Mercurio C., Amigoni F., Cappa A., Fagá G., Fattori R., Legnaghi E., Ciossani G., Mattevi A., Meroni G., Moretti L., Cecatiello V., Pasqualato S., Romussi A., Thaler F., Trifiró P., Villa M., Vultaggio S., Botrugno O.A., Dessanti P., Minucci S., Zagarrí E., Carettoni D., Iuzzolino L., Varasi M., Vianello P.,
Journal of Medicinal Chemistry 60, 1673-1692 (2017)

An algal photoenzyme converts fatty acids to hydrocarbons

Sorigué D., Légeret B., Cuiné S., Blangy S., Moulin S., Billon E., Richaud P., Brugière S., Couté Y., Nurizzo D., Müller P., Brettel K., Pignol D., Arnoux P., Li-Beisson Y., Peltier G., Beisson F.,
Science 357, 903-907 (2017)

Thieno[3,2-b]pyrrole-5-carboxamides as new reversible inhibitors of histone lysine demethylase KDM1A/LSD1. Part 2: Structure-based drug design and structure–activity relationship

Vianello P., Sartori L., Amigoni F., Cappa A., Fagá G., Fattori R., Legnaghi E., Ciossani G., Mattevi A., Meroni G., Moretti L., Cecatiello V., Pasqualato S., Romussi A., Thaler F., Trifiró P., Villa M., Botrugno O.A., Dessanti P., Minucci S., Vultaggio S., Zagarrí E., Varasi M., Mercurio C.,
Journal of Medicinal Chemistry 60, 1693-1715 (2017)

Profiling of flavonol derivatives for the development of antitrypanosomatidic drugs

Borsari C., Luciani R., Pozzi C., Poehner I., Henrich S., Trande M., Cordeiro-Da-Silva A., Santarem N., Baptista C., Tait A., Di Pisa F., Dello Iacono L., Landi G., Gul S., Wolf M., Kuzikov M., Ellinger B., Reinshagen J., Witt G., Gribbon P., Köhler M., Keminer O., Behrens B., Costantino L., Nevado P.T., Bifeld E., Eick J., Clos J., Torrado J., Jiménez-Antón M.D., Corral M.J., Alunda J.M., Pellati F., Wade R.C., Ferrari S., Mangani S., Costi M.P.,
Journal of Medicinal Chemistry 59, 7598-7616 (2016)