Publications RSS feed from the library

Carba-cyclophellitols are neutral retaining-glucosidase inhibitors

Beenakker T.J.M., Wander D.P.A., Offen W.A., Artola M., Raich L., Ferraz M.J., Li K.Y., Houben J.H.P.M., van Rijssel E.R., Hansen T., van der Marel G.A., Codée J.D.C., Aerts J.M.F.G., Rovira C., Davies G.J., Overkleeft H.S.,
Journal of the American Chemical Society 139, 6534-6537 (2017)

Selective nonsteroidal glucocorticoid receptor modulators for the inhaled treatment of pulmonary diseases

Hemmerling M., Nilsson S., Edman K., Eirefelt S., Russell W., Hendrickx R., Johnsson E., Kärrman Mårdh C., Berger M., Rehwinkel H., Abrahamsson A., Dahmén J., Eriksson Anders R., Gabos B., Henriksson K., Hossain N., Ivanova S., Jansson A., Jensen Tina J., Jerre A., Johansson H., Klingstedt T., Lepistö M., Lindsjo M., Mile I., Nikitidis G., Steele J., Tehler U., Wissler L., Hansson T.,
Journal of Medicinal Chemistry 60, 8591-8605 (2017)

A novel non-canonical PIP-box mediates PARG interaction with PCNA

Kaufmann T., Grishkovskaya I., Polyansky A.A., Kostrhon S., Kukolj E., Olek K.M., Herbert S., Beltzung E., Mechtler K., Peterbauer T., Gotzmann J., Zhang L., Hartl M., Zagrovic B., Elsayad K., Djinovic-Carugo K., Slade D.,
Nucleic Acids Research 45, 9741-9759 (2017)

The target landscape of clinical kinase drugs

Klaeger S., Heinzlmeir S., Wilhelm M., Polzer H., Vick B., Koenig P.A., Reinecke M., Ruprecht B., Petzoldt S., Meng C., Zecha J., Reiter K., Qiao H., Helm D., Koch H., Schoof M., Canevari G., Casale E., Depaolini S.R., Feuchtinger A., Wu Z., Schmidt T., Rueckert L., Becker W., Huenges J., Garz A.K., Gohlke B.O., Zolg D.P., Kayser G., Vooder T., Preissner R., Hahne H., Tõnisson N., Kramer K., Götze K., Bassermann F., Schlegl J., Ehrlich H.C., Aiche S., Walch A., Greif P.A., Schneider S., Felder E.R., Ruland J., Médard G., Jeremias I., Spiekermann K., Kuster B.,
Science 358, eaan4368-1-eaan4368-18 (2017)

De novo active sites for resurrected Precambrian enzymes

Risso V.A., Martínez-Rodríguez S., Candel A.M., Krüger D.M., Pantoja-Uceda D., Ortega-Muñoz M., Santoyo-González F., Gaucher E.A., Kamerlin S.C.L., Bruix M., Gavira J.A., Sánchez-Ruiz J.M.,
Nature Communications 8, 16113-1-16113-13 (2017)

Inward H+ pump xenorhodopsin: Mechanism and alternative optogenetic approach

Shevchenko V., Mager T., Kovalev K., Polovinkin V., Alekseev A., Juettner J., Chizhov I., Bamann C., Vavourakis C., Ghai R., Gushchin I., Borshchevskiy V., Rogachev A., Melnikov I., Popov A., Balandin T., Rodriguez-Valera F., Manstein D.J., Bueldt G., Bamberg E., Gordeliy V.,
Science Advances 3, e1603187-1-e1603187-11 (2017)

Biocrystallization of bacterial nucleoid under stress

Sinitsyn D.O., Loiko N.G., Gularyan S.K., Stepanov A.S., Tereshkina K.B., Chulichkov A.L., Nikolaev A.A., El-Registan G.I., Popov V.O., Sokolova O.S., Shaitan K.V., Popov A.N., Krupyansky Y.F.,
Russian Journal of Physical Chemistry B 11, 833-838 (2017)

Ribosomal antibiotics: Contemporary challenges

Auerbach-Nevo T., Baram D., Bashan A., Belousoff M., Breiner E., Davidovich C., Cimicata G., Eyal Z., Halfon Y., Krupkin M., Matzov D., Metz M., Rufayda M., Peretz M., Pick O., Pyetan E., Rozenberg H., Shalev-Benami M., Wekselman I., Zarivach R., Zimmerman E., Assis N., Bloch J., Israeli H., Kalaora R., Lim L., Sade-Falk O., Shapira T., Taha-Salaime L., Tang H., Yonath A.,
Antibiotics 5, 24-1-24-11 (2016)

8-substituted pyrido[3,4-d]pyrimidin-4(3H)-one derivatives as potent, cell permeable, KDM4 (JMJD2) and KDM5 (JARID1) histone lysine demethylase inhibitors

Bavetsias V., Lanigan R.M., Ruda G.F., Atrash B., McLaughlin M.G., Tumber A., Mok N.Y., Le Bihan Y.V., Dempster S., Boxall K.J., Jeganathan F., Hatch S.B., Savitsky P., Velupillai S., Krojer T., England K.S., Sejberg J., Thai C., Donovan A., Pal A., Scozzafava G., Bennett J.M., Kawamura A., Johansson C., Szykowska A., Gileadi C., Burgess-Brown N.A., von Delft F., Oppermann U., Walters Z., Shipley J., Raynaud F.I., Westaway S.M., Prinjha R.K., Fedorov O., Burke R., Schofield C.J., Westwood I.M., Bountra C., Müller S., van Montfort R.L.M., Brennan P.E., Blagg J.,
Journal of Medicinal Chemistry 59, 1388-1409 (2016)