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9 -10 February 2004

Venue:   ESRF, Auditorium  



C. Riekel, ESRF
W. Shepard, ESRF
T. Forsyth, ILL
C. Müller, EMBL

Workshop Secretary:   Isabelle Combe

This Workshop will be held at the ESRF, Grenoble (France) on February 9th and 10th 2004.

Scope of the Workshop

The cell nucleus forms the package for our genes and their controlling factors. In many ways it resembles a cell inside a cell. It has its own chemistry, dynamics and membrane. The study of the processes at work within the nucleus provides fundamental insights into the operation of the enkaryotic cell. Synchrotron radiation scattering techniques have addressed DNA structure and its compaction with proteins at different hierarchical levels of the cell nucleus. Examples are chromatin fibre diffraction and the 3D-structure of the nucleosome core particle. Imaging techniques, such as X-ray microscopy and fluorescence tomography, provide in-situ tools for whole nucleus imaging at ever increasing spatial resolution. Protein crystallographic studies of the key molecules have provided atomic level detail of the interactions controlling nuclear function.

The aim of this workshop is to provide an overview of recent state-of-the-art research and the capabilities and prospects of the different techniques available for the study of the cell nucleus.


 Program and Abstracts