Structure dynamics of microtubules revealed by small- and wide-angle X-ray fiber diffraction

Biomed Seminar Series
Start Date
15-06-2018 14:00
End Date
15-06-2018 15:00
CIBB Seminar Room, second floor
Speaker's name
Shinji Kamimura
Speaker's institute
Department of Biosciences, Faculty of Science and Engineering, Chuo University, Tokio, Japan
Contact name
Claudine Roméro
Host name
Montserrat Soler-Lopez
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Extraordinary Biomed Seminar

by Shinji Kamimura

Prof. Kamimura is interested in the molecular mechanisms of cell motility, in particular the structural background of motor proteins and cytoskeletons, and their evolutionary meaning. i.e., how the polypeptide components and their molecular configurations are optimized for their specific functions. Biological filaments such as microtubules can be readily aligned by shearing flows under various physiological buffer conditions in order to acquire structural periodicity data. In his talk, Prof. Kamimura will provide an introduction of the aligning technique and application to 2D-SAXS/WAXS analysis of microtubules.He will also present recent evidence on how the structures of microtubules as well as their unit molecules, tubulin, are modified depending on various chemical and physical conditions.

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