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Minibeam radiotherapy utilizing novel x-ray sources and conventional irradiators

QUICK INFORMATION
Type
Seminar
Start Date
22-06-2018 11:00
End Date
22-06-2018 12:00
Location
Auditorium, Central Building
Speaker's name
Yueh Z. Lee
Speaker's institute
The University of North Carolina
Contact name
Eva Jahn
Host name
E. Bräuer-Krisch
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Microbeam irradiation is a spatially fractionated radiotherapy technique which allows extremely high dose radiation with minimal effects on normal tissue. The work at the national synchrotron laboratories demonstrated a significant bystander treatment effect, but was difficult to translate to other laboratories. We have developed two different approaches to translate these approaches to other academic centers. The first approach utilizes carbon nanotube x-ray source arrays to increase flux. The second approach utilizes a high resolution collimator approach to MRT adapted to conventional cabinet irradiators. We have explored the utility of these minibeam based approaches in neurocognitive studies in normal mice and in the treatment of melanoma flank models.

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