Wednesday 21 March

13.00 – 14.00            Registration in the ESRF entrance hall

Session 1: Structural Biology with Impact in Biomedical Applications

ESRF auditorium

14.00 – 14.15            Welcome

14.15 – 15.00            Chris Tate (MRC LMB)
                                       "G protein-coupled receptors: from crystals to the clinic"

15.00 – 15.45            Herbert Nar (Boehringer Ingelheim)
                                       "Exploiting allosteric inhibition of GTP Cyclohydrolase I for treating pain disorders"

15.45 – 16.00            Monika Oberer (University of Graz)
                                       "The crystal structure of monoacylglycerol lipase form M. tubercolosis 
                                       reveals the basis for specific inhibition"

16.00 – 16.15            Gérard Bricogne (Global Phasing Ltd)
                                       "Achieving higher performance in high-throughput compound and 
                                       fragment screening campaigns by the use of "Club Class" data 
                                       collection with Pipedream and CRIMS"

16.15 – 16.45            Tea/coffee break 

16.45 – 17.15            Magali Mathieu (Sanofi)
                                       "19F-NMR Fragment Screening at Sanofi"

17.15 – 17.30            María José Sánchez-Barrena (Spanish National Research Council)
                                       "An aminophenothiazine inhibitor of the NCS-1/Ric8a complex 
                                       regulates synaptic function in fragile X syndrome"

17.30 – 17.45            Maayan Gal (Migal - Galilee research center)
                                       "Discovery and development of small-molecule PPIs inhibitor by
                                       computational and biophysical tools"

17.45 – 18.00            Robbie P. Joosten (Netherlands Cancer Institute)
                                       "PDB-REDO: high throughput crystallographic model optimisation"

18.00 – 18.30            Poster Clips

18.30 – 20.30            Wine and cheese buffet, Poster Session in the EMBL-ILL Hallway

Thursday 22 March

Session 2: Infrastructures for Translational Research

ESRF auditorium

09.00 – 09.10            Anastassis Perrakis (Netherlands Cancer Institute)
                                       "Introduction to iNEXT"

09.10 – 09.30            Irina Cornaciu (EMBL Grenoble)
                                       "High-throughput, automated crystallography pipelines for drug discovery"

09.30 – 09.50            Sridhar Sreeramulu (Goethe University)
                                       "NMR quality control and screening capabilities for fragments and beyond"

09.50 – 10.10            Alice Douangamath (Diamond Light Source)
                                       "Fragment screening at Diamond's XChem facility"

10.10 – 10.30            Alexander Fish (NKI)
                                       "Biophysical methods for checking protein-ligand interactions"

10.30 – 11.00            Tea/coffee break

11.00 – 11.30            Lucia Banci (University of Florence)
                                       "Why Instruct is strategic for industry?"

11.30 – 12.15            Matthias Frech (Merck-Serono)
                                       "Drug design in the wider context"

12.15 – 12.30            Organisation of Working Groups - Anastassis Perrakis

12.30 – 14.00            Lunch break (EPN Campus restaurant)

 Session 3: Academia - Industry: Fostering Interactions

ESRF auditorium

14.00 – 14.45            Sandra W. Cowan-Jacob (Novartis Institutes for Biomedical Research)
                                       "Using structural biology to find new approaches to treat Chronic
                                       Myelogenous Leukemia"

14.45 – 15.30            Puja Pathuri (Astex Pharmaceuticals)
                                       "Fragment based drug discovery at Astex"

15.30 – 16.00            Harmut Oschkinat (Leibniz-Institut für Molekulare Pharmakologie)
                                       "Insight into small molecule binding to the neonatal Fc teceptor
                                       by X-ray crystallography and 100 kHz magic-angle-spinning NMR"

16.00 – 16.30            Tea/coffee break

16.30 – 18.30            Working Groups Discussions

19.30 – 22.00            Workshop dinner (restaurant Fantin Latour in Grenoble)

Friday 23 March

Session 4: Emerging Methods - Complementary Approaches 

ESRF auditorium

09.00 – 09.40            Roger Williams (MRC LMB)
                                       "Using HDX-MS, X-ray crystallography and cryo-EM to understand inhibition, activation and dynamics of the PI 3-kinase superfamily"

09.40 – 10.20            Ilaria Ferlenghi (GSK Vaccines)
                                       "Structural vaccinology: a three-dimensional view of vaccine
                                       development"

10.20 – 10.35            Pavel Macek (NMR)
                                       "NMR reveals changes of Hsp90 dynamics upon ligand binding"

10.35 – 11.00            Tea/coffee break

11.00 – 12.00            Working Groups Wrap-Up

12.00 – 12.45            Stephen Cusack (EMBL Grenoble)
                                       "The mechanism of transcription by influenza polymerase and how to
                                       inhibit it"

12.45 – 13.00            Closing Remarks

13.00                           End of Meeting