The following publications cover the period Sept 2003 -Jan 2007. The list is not definitive and we rely on user feedback to keep it updated - we ask all BM16 users to inform us of any papers published or PDB submissions arising from experiments carried out at BM16 by sending an email here.

 

In-house publications      

2007

 

Fox GC, Shafiq M, Briggs DC, Knowles PP, Collister M, Didmon MJ, Makrantoni V, Dickinson RJ, Hanrahan S, Totty N, Stark MJ, Keyse SM, McDonald NQ.

Redox-mediated substrate recognition by Sdp1 defines a new group of tyrosine phosphatases.

Nature. 2007 May 24;447(7143):487-92.

Hermo-Parrado XL, Guardado-Calvo P, Llamas-Saiz AL, Fox GC, Vazquez-Iglesias L, Martínez-Costas J, Benavente J, van Raaij MJ.

Crystallization of the avian reovirus double-stranded RNA-binding and core protein sigmaA

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 May 1;63(Pt 5):426-9.

Guardado-Calvo P, Llamas-Saiz AL, Fox GC, Langlois P, van Raaij MJ.

Structure of the C-terminal head domain of the fowl adenovirus type 1 long fiber.

J Gen Virol. 2007 Sep;88(Pt 9):2407-16.

Brissett NC, Pitcher RS, Juarez R, Picher AJ, Green AJ, Dafforn TR, Fox GC, Blanco L, Doherty AJ.

Structure of a NHEJ polymerase-mediated DNA synaptic complex

Science. 2007 Oct 19;318(5849):456-9.

Pitcher RS, Brissett NC, Picher AJ, Andrade P, Juarez R, Thompson D, Fox GC, Blanco L, Doherty AJ.

Structure and function of a mycobacterial NHEJ DNA repair polymerase.

J Mol Biol. 2007 Feb 16;366(2):391-405. 

 

2006

 

Rueda D.R., García Gutiérrez M.C., Nogales A., Capitán M.J., Ezquerra T.A., Labrador A., Fragua E., Beltrán D., Juanhuix J., Herranz J.F., Bordas J.
Versatile wide angle diffraction setup for simultaneous wide and small angle X-ray scattering measurements with synchrotron radiation

Rev. sci. instrum. 77, 033904-1-033904-5 (2006)

Erskine P.T., Knight M.J., Ruaux A., Mikolajek H., Wong Fat Sang N., Withers J., Gill R., Wood S.P., Wood M., Fox G.C., Cooper J.B.
High resolution structure of BipD: An invasion protein associated with the type III secretion system of Burkholderia pseudomallei

J. mol. biol. 363, 125-136 (2006)

Erskine PT, Beaven GD, Hagan R, Findlow IS, Werner JM, Wood SP, Vernon J, Giese KP, Fox G, Cooper JB.

Structure of the neuronal protein calexcitin suggests a mode of interaction in signalling pathways of learning and memory.

J Mol Biol. 2006 Apr 14;357(5):1536-47.  

 

 

 

2005

 

Margiolaki I, Wright JP, Fitch AN, Fox GC, Von Dreele RB.

Synchrotron X-ray powder diffraction study of hexagonal turkey egg-white lysozyme

Acta Crystallogr D Biol Crystallogr. 2005 Apr;61(Pt 4):423-32

 

  Guardado Calvo P, Fox GC, Hermo Parrado XL, Llamas-Saiz AL, Costas C, Martínez-Costas J, Benavente J, van Raaij MJ.

Structure of the carboxy-terminal receptor-binding domain of avian reovirus fibre sigmaC.

J Mol Biol. 2005 Nov 18;354(1):137-49.

Basso S, Fitch AN, Fox GC, Margiolaki I, Wright JP.
High-throughput phase-diagram mapping via powder diffraction: a case study of HEWL versus pH.
Acta Crystallogr D Biol Crystallogr. 2005 Dec;61(Pt 12):1612-25.


van Raaij MJ, Hermo Parrado XL, Guardado Calvo P, Fox GC, Llamas-Saiz AL, Costas C, Martínez-Costas J, Benavente J.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jul 1;61(Pt 7):651-4.  

Juanhuix J, Labrador A, Beltran D, Herranz J.F, Carpentier P, Bordas J.

The macromolecular crystallography station at beamline BM16 at the ESRF.

Rev Sci Inst; 76 (1) (2005)

Margiolaki, I. ; Wright, J. ; Basso, S. ; Fitch, A. ; Fox, G. C. ; Schiltz, M. ; Pattison, P. ; Von Dreele, R.
Development of powder diffraction methods for macromolecular crystallography

Acta Crystallographica Section A, vol. 61 (2005), p. C54

McGeehan JE, Streeter SD, Papapanagiotou I, Fox GC, Kneale GG.

High-resolution crystal structure of the restriction-modification controller protein C.AhdI from Aeromonas hydrophila.

J Mol Biol. 25;346:689-701 (2005)

 

2004

 

McGeehan JE, Streeter S, Cooper JB, Mohammed F, Fox GC, Kneale GC.
Crystallization and preliminary X-ray analysis of the controller protein C.AhdI from Aeromonas hydrophilia.

Acta Crystallogr D Biol Crystallogr. 2004 Feb;60(Pt 2):323

 

Toledo J, Beltran D, Bordas J, Ramos-Lerate I, Martinez J.C, Fernandez F.
Fast & compact data acquisition for gas-filled detectors with delay-line.
IEEE Trans Nucl Sci; 51 (4):1488-91 (2004)

 

Toledo J., Beltrán D., Bordas J., Ramos-Lerate I., Martínez J.C., Fernández F.

A fast and compact histogramming solution for gas-filled detectors with delay line.

IEEE Proceedings 3, 1685-1688 (2004)

 

2003

 

Gaboriaud C, Juanhuix J, Gruez A, Lacroix M, Darnault C, Pignol D, Verger D, Fontecilla-Camps JC, Arlaud GJ.
The crystal structure of the globular head of complement protein C1q provides a basis for its versatile recognition properties.

J Biol Chem; 278(47):46974-82. (2003)

 

 

User publications

2008

 

 

2007

PX

Garriga, D.,  Navarro, A.,  Querol-Audi, J.,  Abaitua, F.,  Rodriguez, J.F.,  Verdaguer, N. Activation mechanism of a noncanonical RNA-dependent RNA polymerase. Proc.Natl.Acad.Sci.Usa 104: 20540-20545

(2007)

Gill D.J., Teo H., Sun J., Perisic O., Veprintsev D.B., Emr S.D., Williams R.L., - Structural insight into the ESCRT-I/-II link and its role in MVB trafficking EMBO Journal 26, 600-612 (2007) Gallego del Sol F., Cavada B.S., Calvete J.J., - Crystal structures of Cratylia floribunda seed lectin at acidic and basic pHs. Insights into the structural basis of the pH-dependent dimer–tetramer transition Journal of Structural Biology 158,

1-9 (2007)

Kožíšek M. , Bray J. , Rezácová P. , Šašková K. , Brynda J. , Pokorná J. , Mammano F. , Rulíšek L. , Konvalinka J. - Molecular analysis of the HIV-1 resistance development: Enzymatic activities, crystal structures, and thermodynamics of nelfinavir-resistant HIV protease mutants
Journal of Molecular Biology 374, 1005-1016 (2007)

Popa M. , Pradell T. , Crespo D. , Calderón-Moreno J.M. - Stable silver colloidal dispersions using short chain polyethylene glycol
Colloids and Surfaces A 303, 184-190 (2007)

Santillana, E.,  Beceiro, A.,  Bou, G.,  Romero, A. Crystal Structure of the Carbapenemase Oxa-24 Reveals Insights Into the Mechanism of Carbapenem Hydrolysis. Proc.Natl.Acad.Sci.USA v104 pp.5354 , 2007

Isorna P, Polaina J, Latorre-García L, Cañada F.J., González B., Sanz-Aparicio J., - Crystal structures of Paenibacillus polymyxa beta-glucosidase B complexes reveal the molecular basis of substrate specificity and give new insights into the catalytic machinery of family I glycosidases Journal of Molecular Biology 371, 1204-1218 (2007)

Garlatti V., Belloy N., Martin L., Lacroix M., Matsushita M., Endo Y., Fujita T., Fontecilla-Camps J.C., Arlaud G.J., Thielens N.M., Gaboriaud C., - Structural insights into the innate immune recognition specificities of L- and H-ficolins EMBO Journal 26, 623-633 (2007)

Arribas-Bosacoma, R.,  Kim, S.-K.,  Ferrer-Orta, C.,  Blanco, A.G.,  Pereira, P.J.B.,  Gomis-Ruth, F.X.,  Wanner, B.L.,  Coll, M.,  Sola, M. The X-Ray Crystal Structures of Two Constitutively Active Mutants of the Escherichia Coli Phob Receiver Domain Give Insights Into Activation. J.Mol.Biol. v366 pp.626 , 2007

Santiago, C.,  Ballesteros, A.,  Tami, C.,  Martinez-Munoz, L.,  Kaplan, G.G.,  Casasnovas, J.M. Structures of T Cell Immunoglobulin Mucin Receptors 1 and 2 Reveal Mechanisms for Regulation of Immune Responses by the TIM Receptor Family. Immunity v26 pp.299-310 , 2007

García-Castellanos R., Tallant C., Marrero A., Solà M., Baumann U., Gomis-Rüth F.X. - Substrate specificity of a metalloprotease of the pappalysin family revealed by an inhibitor and a product complex Archives of Biochemistry and Biophysics 457, 57-72 (2007)

Llacer JL, Polo LM, Tavarez S, Alarcon B, Hilario R, Rubio V The gene cluster for agmatine catabolism of Enterococcus faecalis: study of recombinant putrescine transcarbamylase and agmatine deiminase and a snapshot of agmatine deiminase catalyzing its reaction. J Bacteriol. 2007 Feb;189(4):1254-65. Epub 2006 Oct 6

Marco-Marin C, Gil-Ortiz F, Perez-Arellano I, Cervera J, Fita I, Rubio V A Novel Two-domain Architecture Within the Amino Acid Kinase Enzyme Family Revealed by the Crystal Structure of Escherichia coli Glutamate 5-kinase.J Mol Biol. 2007 Feb 3;

Godoy-Ruiz, R.,  Gavira, J.A.,  Ibarra-Molero, B.,  Sanchez-Ruiz, J.M. Crystal Structure of Thioredoxin Mutant D47E in Hexagonal (p61) Space Group To be Published

2006

NCD

Garcia Gutiérrez M.C., Nogales A., Rueda D.R., Domingo C., García-Ramos J.V., Broza G., Roslaniec Z., Schulte K., Davies R.J., Ezquerra T.A. Templating of crystallization and shear-induced self-assembly of single-wall carbon nanotubes in a polymer-nanocomposite. Polymer 47, 341-345 (2006)

 Rueda D.R., García Gutiérrez M.C., Nogales A., Capitán M.J., Ezquerra T.A., Labrador A., Fragua E., Beltrán D., Juanhuix J., Herranz J.F., Bordas J. - Versatile wide angle diffraction setup for simultaneous wide and small angle X-ray scattering measurements with synchrotron radiation
Rev. sci. instrum. 77, 033904-1-033904-5 (2006)

PX

Cavada, B.S.,  Moreno, F.B.,  da Rocha, B.A.,  de Azevedo Jr., W.F.,  Castellon, R.E.R.,  Goersch, G.V.,  Nagano, C.S.,  de Souza, E.P.,  Nascimento, K.S.,  Radis-Baptista, G.,  Delatorre, P.,  Leroy, Y.,  Toyama, M.H.,  Pinto, V.P.,  Sampaio, A.H.,  Barettino, D.,  Debray, H.,  Calvete, J.J.,  Sanz, L. cDNA cloning and 1.75 A crystal structure determination of PPL2, an endochitinase and N-acetylglucosamine-binding hemagglutinin from Parkia platycephala seeds Febs J. 273: 3962-3974(2006)

Kondo J., Urzhumtsev A., Westhof E. - Two conformational states in the crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site Nucleic acids res. 34, 676-685 (2006)
Ferrer-Orta C., Arias A., Agudo R., Pérez-Luque R., Escarmís C., Domingo E., Verdaguer N. - The structure of a protein primer–polymerase complex in the initiation of genome replication EMBO j. 25, 880-888 (2006)

Johnson S., Roversi P., Espina M., Deane J.E., Birket S., Picking W.D., Blocker A., Picking W.L., Lea S.M. - Expression, limited proteolysis and preliminary crystallographic analysis of IpaD, a component of the Shigella flexneri type III secretion system Acta Crystallographica F 62

, 865-868 (2006)

Gavira J.A., de Jesus W, Camara-Artigas A., López-Garriga J., García-Ruiz J.M. - Capillary crystallization and molecular-replacement solution of haemoglobin II from the clam Lucina pectinata Acta Crystallographica F 62, 196-199 (2006)
Goulet A., Spinelli S., Campanacci V., Porciero S., Blangy S., Garrett R.A., van Tilbeurgh H., Leulliot N., Basta T., Prangishvili D., Cambillau C. - Crystallization and preliminary X-ray diffraction analysis of protein 14 from Sulfolobus islandicus filamentous virus (SIFV) Acta Crystallographica F 62, 884-886 (2006)
Horcajada C., Guinovart J.J., Fita I., Ferrer J.C. - Crystal structure of an archaeal glycogen synthase. Insights into oligomerization and substrate binding of eukaryotic glycogen synthetases J. biol. chem. 281

, 2923-2931 (2006)

Marrero, A., Mallorqui-Fernandez, G., Guevara, T., Garcia-Castellanos, R., Gomis-Ruth, F.X. Unbound and Acylated Structures of the Mecr1 Extracellular Antibiotic-Sensor Domain Provide Insights Into the Signal-Transduction System that Triggers Methicillin Resistance. J.Mol.Biol. 361 :506 (2006)

Campos L., Valls N., Urpí L., Gouyette C., Sanmartín T., Richter M., Alechaga E., Santaolalla A., Baldini R., Creixell M., Ciurans R., Skokan P., Pous J., Subirana J.A. - Overview of the structure of all-AT oligonucleotides: Organization in helices and packing interactions Biophys. j. 91, 892-903 (2006)

Capellas Espuny M. - Tumours meet their match in designer drugs ESRF Newsletter 43, 11 (2006)

Boer R., Russi S., Guasch A., Lucas M., Blanco A.G., Perez-Luque R., Coll M., De La Cruz F. - Unveiling the molecular mechanism of a conjugative relaxase: The structure of TrwC complexed with a 27-mer DNA comprising the recognition hairpin and the cleavage site J. mol. biol. 358, 857-869 (2006)

Lowe E.D., Hasan Na'il, Trempe J.F., Fonso L., Noble M.E.M., Endicott J.A., Johnson L.N., Brown N.R. - Structures of the Dsk2 UBL and UBA domains and their complex Acta crystallogr., Sect. D 62, 177-188 (2006)

Gallego del Sol, F.G.,Cavada, B.S.,Calvete, J.J. Crystal structure of Cratylia floribunda seed lectin. TO BE PUBLISHED (2006)

C.TALLANT,R.GARCIA-CASTELLANOS,J.SECO,U.BAUMANN,F.X.GOMIS-RUTH. MOLECULAR ANALYSIS OF ULILYSIN, THE STRUCTURAL PROTOTYPE OF A NEW FAMILY OF METZINCIN METALLOPROTEASES. J.Biol.Chem. 281:17920 (2006)

N.VALLS,A.SANTAOLALLA,L.CAMPOS,J.A.SUBIRANA. STRUCTURE OF THE OLIGONUCLEOTIDE D(AAATTT) TO BE PUBLISHED (2006)

A.OLEKSI,A.G.BLANCO,R.BOER,I.USON,J.AYMAMI, A.RODGER,M.J.HANNON,M.COLL. MOLECULAR RECOGNITION OF A THREE-WAY DNA JUNCTION BY A METALLOSUPRAMOLECULAR HELICATE. ANGEW.CHEM.INT.ED.ENGL.V.45 1227 (2006)

F.GALLEGO DEL SOL,B.S.CAVADA,J.J.CALVETE CRATYLIA FOLIBUNDA SEED LECTIN AT ACIDIC PH. to be published (2006)

D.DE LUCHI,V.TERESHKO,C.GOUYETTE,J.A.SUBIRANA. STRUCTURE OF THE DNA COILED COIL FORMED BY D(CGATATATATAT) CHEMBIOCHEM 7 585 (2006).

Carpena X, Wiseman B, Deemagarn T, Herguedas B, Ivancich A, Singh R, Loewen PC, Fita I. Roles for Arg426 and Trp111 in the modulation of NADH oxidase activity of the catalase-peroxidase KatG from Burkholderia pseudomallei inferred from pH-induced structural changes.Biochemistry. (2006) Apr 25;45(16):5171-9.

Marrero A., Mallorquí-Fernández G., Guevara T., García-Castellanos R., Gomis-Rüth F.X. - Unbound and acylated structures of the MecR1 extracellular antibiotic-sensor domain provide insights into the signal-transduction system that triggers methicillin resistance J. mol. biol. 361, 506-521 (2006)

Solà M., Drew D.L., Blanco A.G., Gomis-Rüth F.X., Coll M. - The cofactor-induced pre-active conformation in PhoB Acta crystallogr., Sect. D 62, 1046-1057 (2006)

van Eerde A., Wolterink-van Loo S., van der Oost J., Dijkstra B.W. - Fortuitous structure determination of `as-isolated' Escherichia coli bacterioferritin in a novel crystal form
Acta Crystallographica F 62, 1061-1066 (2006)

 

2005

 

 

Gallego Del Sol, F.,Nagano, C.,Cavada, B.S.,Calvete, J.J. The first crystal structure of a mimosoideae lectin reveals a novel quaternary arrangement of a widespread domain. J.Mol.Biol. 353 574 (2005)

Albert, A.,Munoz-Espin, D.,Jimenez, M.,Asensio, J.L.,Hermoso, J.A.,Salas, M., Meijer, W.J.J. Structural Basis for Membrane Anchorage of Viral Phi 29 DNA During Replication. J.Biol.Chem. 280. 42486 (2005)

R.VAINER,V.BELAKHOV,E.RABKIN,T.BAASOV,N.ADIR CRYSTAL STRUCTURES OF ESCHERICHIA COLI KDO8P SYNTHASE COMPLEXES REVEAL THE SOURCE OF CATALYTIC IRREVERSIBILITY J.MOL.BIOL. 351 641 (2005)

Marco-Marin, C.,Gil-Ortiz, F.,Rubio, V. The Crystal Structure of Pyrococcus Furiosus Ump Kinase Provides Insight Into Catalysis and Regulation in Microbial Pyrimidine Nucleotide Biosynthesis. J.Mol.Biol. 352 438 (2005)

Marco-Marín C., Escamilla-Honrubia J.M., Rubio V. - First-time crystallization and preliminary X-ray crystallographic analysis of a bacterial-archaeal type UMP kinase, a key enzyme in microbial pyrimidine biosynthesis. Biochim. biophys. acta 1747, 271-275 (2005)

Sanchez-Barrena, M., Martinez-Ripoll, M., Zhu, J., Albert, A. The Structure of the Arabidopsis Thaliana SOS3: Molecular Mechanism of Sensing Calcium for Salt Stress Response. J Mol Biol; 345: 1253 (2005) (Cover Issue).

Asensio, J. L., Albert, A., Munoz-Espin, D., Gonzalez, C., Hermoso, J. A., Villar, L., Jimenez-Barbero, J., Salas, M., Meijer, W. J. J.: Structure of the Functional Domain of {Varphi}29 Replication Organizer: Insights Into Oligomerization and DNA Binding. J Biol Chem; 280: 20730 (2005).

Mancheno JM, Tateno H, Goldstein IJ, Martinez-Ripoll M, Hermoso JA. Structural analysis of the Laetiporus sulphureus hemolytic pore-forming lectin in complex with sugars. J Biol Chem; 280(17): 17251-9 (2005).

Fernandez-Tornero C, Garcia E, de Pascual-Teresa B, Lopez R, Gimenez-Gallego G, Romero A. Ofloxacin-like antibiotics inhibit pneumococcal cell wall-degrading virulence factors. J Biol Chem; 280(20):19948-57 (2005).

Rukhman V., Anati R., Melamed-Frank M., Adir N. - The MntC crystal structure suggests that import of Mn2+ in cyanobacteria is redox controlled. J. mol. biol. 348, 961-969 (2005)

Lopez-Jaramillo FJ., Perez-Banderas F., Hernandez-Mateo F., Santoyo-Gonzalez F. Production, crystallization and X-ray characterization of chemically glycosylated hen egg-white lysozyme. Acta Crystallogr F; 61: 435–438 (2005).

Campos J.L., Urpí L., Sanmartín T., Gouyette C., Subirana J.A. - DNA coiled coils Proc. Natl. Acad. Sci. U. S. A. 102, 3663-3666 (2005)

Valls N, Richter M, Subirana JA. Structure of a DNA duplex with all-AT base pairs. Acta Crystallogr D Biol Crystallogr. 61:1587 (2005)

N.Valls, J.A. Subirana. Crystalline DNA structures stabilized by transition metals. J.Biomol.Struct. Dyn. 22, 783 (2005)

L. Urpí, J.L. Campos, N. Valls, T. Sanmartin, E. Alechaga, R. Baldini, D. de Luchi, M. Richter, A. Santaolalla, C. Gouyette, J.A. Subirana Structural features of AT oligomers studied by X-Ray crystallography. J.Biomol.Struct. Dyn. 22, 847 (2005)

A molecular switch and electronic circuit modulate catalase activity in catalase-peroxidases. Xavier Carpena, Ben Wiseman, Taweewat Deemagarn, Rahul Singh, Jacek Switala , Anabella Ivancich, Ignacio Fita and Peter C. Loewen. (EMBO Rep) 6 1156 (2005)

Nagano C.S., Gallego del Sol F., Cavada B.S., Santiago do Nascimento K., Vale Nunes E., Sampaio A.H., Calvete J.J. - Crystallization and preliminary X-ray diffraction analysis of HML, a lectin from the red marine alga Hypnea musciformis Acta Crystallographica F 61, 997-999 (2005)

Deemagarn T, Carpena X, Singh R, Wiseman B, Fita I, Loewen PC. Structural characterization of the Ser324Thr variant of the catalase-peroxidase (KatG) from Burkholderia pseudomallei.J Mol Biol.;345(1):21-8.(2005)

 

 

2004

 

 

Sanchez-Barrena MJ, Martinez-Ripoll M, Zhu JK, Albert A. SOS3 (salt overly sensitive 3) from Arabidopsis thaliana: expression, purification, crystallization and preliminary X-ray analysis. Acta Crystallogr D; 60: 1272-4. (2004)

Perez-Dorado I, Bittel C, Cortez N, Hermoso JA. Crystallization and preliminary X-ray diffraction analysis of ferredoxin-NADP(H) reductase from Rhodobacter capsulatus Acta Crystallogr D; 60: 2332-5 (2004)

Mancheno JM, Tateno H, Goldstein IJ, Hermoso JA. Crystallization and preliminary crystallographic analysis of a novel haemolytic lectin from the mushroom Laetiporus sulphureus. Acta Crystallogr D; 60:1139-41 (2004)

Perez-Arellano I, Gil-Ortiz F, Cervera J, Rubio V. Glutamate-5-kinase from Escherichia coli: gene cloning, overexpression, purification and crystallization of the recombinant enzyme and preliminary X-ray studies. Acta Crystallogr D; 60: 2091-4 (2004)